Computational Analysis Of Potential Key Genes Associated With Dopamine Neurotransmission In Pheochromocytoma And Paraganglioma

Pheochromocytoma and Paraganglioma (PCPG) are rare potentially lethal neuroendocrine tumors. PCPG that predominantly or exclusively produce secrete DA is rarely seen it has been known dopamine-secreting related with advanced malignant features metastases. Up to the present, little about role of dopamine neurotransmission dopaminergic system in initiation progression PCPG. The genes significant expression differences between normal tissue pheochromocytoma paraganglioma, survival correlation analysis, CpG islands prediction, miRNA-target enrichment analysis were performed by several bioinformatics tools. In present study, was determined COMT gene significantly less expressed than showed a remarkable relationship differential shorter overall among individuals (HR=1, p=0.011). MAOA pair correlated (p=0.012; R=0.19) hsa-miR-5000-5p regulates both (p=0.00215, FDR=0.127). Our findings suppose may be implicated tumor suppressive mechanism. values genes, have potential used genetic evaluation pathogenesis prognosis Further vitro vivo studies required clarify molecular mechanism